Síntese de análogos de diidrocumarinas e avaliação da atividade anticolinesterásica

Abstract

Diidrocumarinas are neoflavonoides that have a diverse pharmacological potential. In this work, we performed the synthesis of structural analogues diidrocumarinas in order to obtain biologically active compounds against the enzyme acetylcholinesterase (related to Alzheimer's disease). Li and employees described in their report the possibility to synthesize diidrocumarinas with excellent yields by hidroarilação of olefins catalyzed by trifluoroacetic acid (TFA). In this work, the olefins used are cinnamic esters obtained from the reaction between phosphorus Ilides and benzaldehydes as well as cinnamic acids obtained commercially. These compounds react with phenols by condensation obtained the diidrocumarinas. After the synthesis, purification by flash chromatography and characterization by spectrometric methods such as infrared (IR) and nuclear magnetic resonance (NMR) tests were performed for biological activity anticholinesterase, obtaining a positive response for all compounds.